Los Angeles: "Pluribus", "The Pitt" and "Hacks" are expected to be amongst the biggest contenders as Emmy nominations are announced on Wednesday.Recent winners Liza Colón-Zayas and Jeff Hiller will announce the nominees in Los Angeles. The 78th Primetime Emmy Awards will be held on September 14 at the Peacock Theater in Los Angeles, with Mariska Hargitay set to host.Among the top drama contenders is HBO Max's "The Pitt", which won major awards last year, including best drama series, best actor for Noah Wyle and best supporting actress for Katherine LaNasa. Wyle and LaNasa are widely expected to earn nominations again, with several cast members also likely to feature in the supporting acting categories.Another major contender is "Pluribus", the Apple TV series from "Breaking Bad" and "Better Call Saul" creator Vince Gilligan. The show could challenge the record for the most Emmy nominations for a debut season, set by "NYPD Blue" with 26 in 1994. Rhea Seehorn is also expected to receive a best actress nomination after her Golden Globes win.In the comedy categories, Emmy voters are expected to continue backing "Hacks", whose fifth and final season is tipped for another strong showing. Star Jean Smart is seeking a fifth consecutive best actress nomination, while Hannah Einbinder and the show's co-creator Paul W. Downs are also expected to be recognised."Shrinking" is another strong comedy contender, with Harrison Ford expected to compete for best supporting actor and Jason Segel also likely to receive a nomination. Apple TV could also see nominations for "Margo's Got Money Troubles" and the horror comedy "Widow's Bay".In the limited or anthology series categories, Netflix's "Beef" is expected to be among the leading contenders, with FX's "Love Story: John F. Kennedy Jr. & Carolyn Bessette" among its main rivals.Potential guest acting nominees include the late Rob Reiner for "The Bear" and Michael J. Fox for his role in "Shrinking".